These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Comparative study of analgesic potency of ACTH4-10 fragment and its analog semax.
    Author: Ivanova DM, Levitskaya NG, Andreeva LA, Kamenskii AA, Myasoedov NF.
    Journal: Bull Exp Biol Med; 2007 Jan; 143(1):5-8. PubMed ID: 18018999.
    Abstract:
    The effects of ACTH4-10 fragment and its analog semax on nociception were examined on various animal models. ACTH4-10 in a dose of 0.5 mg/kg decreased nociception in rats during hindpaw compression test and in mice subjected to acetic acid writhing test. Lower doses of ACTH4-10 produced no analgesic effect. Semax (0.015-0.500 mg/kg) decreased pain sensitivity in all experimental models. Hence, the substitution of three C-terminal amino acid residues in ACTH4-10 for Pro-Gly-Pro sequence augmented the analgesic potency of the peptide after its peripheral injection.
    [Abstract] [Full Text] [Related] [New Search]