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  • Title: Pulmonary alveolar proteinosis as a component of massive fibrosis in cases of chronic pneumoconiosis. An autopsy study of 79 cases.
    Author: Honma K, Chiyotani K.
    Journal: Zentralbl Pathol; 1991; 137(5):414-7. PubMed ID: 1801911.
    Abstract:
    Histopathological analysis of massive fibrosis (MF) in lungs obtained from 79 patients with chronic pneumoconiosis revealed evidence of pulmonary alveolar proteinosis (AP) in a surprisingly high proportion of the cases (73%), suggesting that AP may be a usual constituent of MF in chronic pneumoconiosis. AP is not a specific morphological counterpart responsible for acute silicosis. In order to explain the occurrence of AP in MF, several hypothetical mechanisms are proposed and discussed.
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