These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Serum pepsinogen levels in the Japanese population: prospective study of 9 years of follow-up.
    Author: Xie XF, Ito M, Yoshihara M, Haruma K, Tanaka S, Chayama K.
    Journal: Hepatogastroenterology; 2007 Sep; 54(78):1887-90. PubMed ID: 18019741.
    Abstract:
    BACKGROUND/AIMS: Natural alterations of serum pepsinogen (PG) levels are still unclear. We investigated the natural course of pepsinogen levels by prospective study over a period of 9 years. METHODOLOGY: Out of 18,676 participants of a cancer screening program, 262 individuals (79 males, mean age 58.6 years) were enrolled. Sera were obtained from all participants in 1989 and again in 1998 to screen for gastric cancer. PG concentrations were determined by radioimmunoassay. Subjects with a PGI concentration of > 50 or a PGI/II ratio of > 3 were considered PG-negative. RESULTS: Initially, 207 and 55 subjects were considered to be PG-negative and positive, respectively. Of the 207 PG-negative subjects, 25 (12.1%) had seroconverted to a PG-positive status. All of the 41 subjects with a PGI/II ratio > 6.5, in whom H. pylori should be negative, remained PG-negative. Seroconversion to a PG-positive status was more frequently found in subjects with PGII > 15ng/mL, in whom active gastritis is more likely to be present. Of the 55 with PG-positive subjects, as assessed in 1989, 18 (32.7%) had seroconversion to a PG-negative status. CONCLUSIONS: PG-seroconversion occurred in 16% of people over a 9-year period. Seroconversion to a PG-positive status may be induced by active gastritis.
    [Abstract] [Full Text] [Related] [New Search]