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  • Title: Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor.
    Author: Song EY, Kaur N, Park MY, Jin Y, Lee K, Kim G, Lee KY, Yang JS, Shin JH, Nam KY, No KT, Han G.
    Journal: Eur J Med Chem; 2008 Jul; 43(7):1519-24. PubMed ID: 18023932.
    Abstract:
    A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
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