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  • Title: Frequencies of HLA-DR3, -DR4, -B8 and -Bw62 in diabetic children diagnosed between 1960 and 1990.
    Author: Mäenpää A, Koskimies S, Scheinin T, Schlenzka A, Akerblom HK, Mäenpää J, Reunanen A, Kontiainen S.
    Journal: Diabetes Res; 1991 Apr; 16(4):159-63. PubMed ID: 1802481.
    Abstract:
    An analysis of the HLA-types of 351 children in whom a diagnosis of insulin dependent diabetes mellitus (IDDM) had been made between 1960 and 1990 revealed that although the frequencies of HLA-DR3, -DR4, -DR3/4, -B8 and -Bw62 were increased there was, depending on the year of diagnosis, a marked fluctuation in the frequencies of these HLA-antigens and in the frequency with which -B8 was associated with -DR3 and -Bw62 with -DR4 suggesting heterogeneity/variation in agents initiating/triggering IDDM.
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