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  • Title: Single nucleotide polymorphism mapping array assay.
    Author: Zhou X, Wong DT.
    Journal: Methods Mol Biol; 2007; 396():295-314. PubMed ID: 18025700.
    Abstract:
    Single nucleotide polymorphisms (SNPs) are the most frequent form of DNA variation present in the human genome, and millions of SNPs have been identified http://www.ncbi.nlm.nih.gov/SNP/). Because of their abundance, even spacing, and stability across the genome, SNPs have significant advantages over other genetic markers (such as restriction fragment length polymorphisms and microsatellite markers) as a basis for high-resolution whole genome allelotyping. SNP scoring is easily automated and high-density oligonucleotide arrays have recently been generated to support large-scale high throughput SNP analysis. High-density SNP allele arrays have improved significantly and it is now possible to genotype hundreds of thousands SNP markers using a single SNP array. In this chapter, we will provide a detailed experimental protocol of Affymetrix GeneChip SNP Mapping Array-based whole genome SNP genotyping assay.
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