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Title: Possible requirement of intercellular adhesion molecule-1 for invasion of gingival epithelial cells by Treponema medium. Author: Tamai R, Asai Y, Kawabata A, Akisaka T, Ogawa T. Journal: Can J Microbiol; 2007 Nov; 53(11):1232-8. PubMed ID: 18026217. Abstract: Oral treponemes are members of the spirochete family of bacteria associated with periodontal diseases. In the present study, we demonstrate that intercellular adhesion molecule-1 (ICAM-1) on human gingival epithelial cells (HGEC) contributed to the invasion of Treponema medium, a medium-sized oral Treponema, into those cells. The quantity of T. medium in HGEC was found to peak at 2 h after inoculation and then decreased gradually. Immunofluorescence microscopy findings showed that the bacteria were colocalized with ICAM-1 on HGEC. Furthermore, knockdown of ICAM-1 in HGEC resulted in inhibition of T. medium invasion by RNA interference, whereas that of Toll-like receptor 2 did not. These results suggest that ICAM-1 may be required for the invasion of T. medium into HGEC, and they indicate that the molecule plays a principal role in the primary stages of the development and progression of chronic periodontitis.[Abstract] [Full Text] [Related] [New Search]