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  • Title: Niphatoxin C, a cytotoxic tripyridine alkaloid from Callyspongia sp.
    Author: Buchanan MS, Carroll AR, Addepalli R, Avery VM, Hooper JN, Quinn RJ.
    Journal: J Nat Prod; 2007 Dec; 70(12):2040-1. PubMed ID: 18027906.
    Abstract:
    As part of our studies to discover P2X 7 receptor antagonists, the sponge Callyspongia sp. was investigated. A new tripyridine alkaloid niphatoxin C ( 1) was isolated and had P2X 7 receptor antagonism; however, cytotoxicity of THP-1 cells was the predominant biological effect at higher concentrations. Its structure was determined by 1- and 2-D NMR spectroscopy.
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