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  • Title: Electrochemical and fluorescence detection of cytosine-related SNPs using a ferrocenyl naphthyridine derivative.
    Author: Morita K, Sato Y, Seino T, Nishizawa S, Teramae N.
    Journal: Nucleic Acids Symp Ser (Oxf); 2007; (51):295-6. PubMed ID: 18029703.
    Abstract:
    A novel hydrogen bond-forming ligand for cytosine-related single nucleotide polymorphism, which contains both a fluorescent naphthyridine moiety and a ferrocene group as an electrochemical indicator, is described. Hydrogen bond-mediated recognition for a target nucleobase within an abasic site-containing DNA duplex was confirmed by both fluorescence and electrochemical measurements. The analysis by fluorescence titration reveals that the ligand shows significant fluorescent quenching upon formation of a 1: 1 complex with the target nucleobase opposite an AP site, and the selectivity was in the order of cytosine > thymine > adenine, guanine, reflecting the stability of hydrogen bond formation.
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