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  • Title: Synthesis and evaluation of 9-deazaguanine derivatives as multi-substrate analogue inhibitors of PNP.
    Author: Hashimoto M, Hikishima S, Magnowska L, Bzowska A, Yokomatsu T.
    Journal: Nucleic Acids Symp Ser (Oxf); 2007; (51):431-2. PubMed ID: 18029771.
    Abstract:
    9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguanine (DFPP-DG) and its related analogues were designed as multi-substrate analogue inhibitors against purine nucleoside phosphorylase (PNP) on the basis of the X-ray crystallographic data obtained for the binary complex of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine (DFPP-G) with calf-spleen PNP. One of these analogues, homo-DFPP-DG was found to be a very potent PNP inhibitor at an intracellular P(i) concentration (about 1 mM phosphate).
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