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  • Title: [Neoadjuvant chemotherapy in muscle-invasive bladder cancer].
    Author: Miyanaga N, Akaza H.
    Journal: Gan To Kagaku Ryoho; 2007 Nov; 34(11):1745-9. PubMed ID: 18030008.
    Abstract:
    Radical cystectomy is the standard treatment for patients with muscle-invasive bladder cancer. Bladder cancer is a chemoresponsive disease and should be dealt with in a multimodality approach. Neoadjuvant chemotherapy is intended for patients with operable clinical stage T2 to T4a muscle-invasive disease to improve survival. Meta-analysis of cisplatin-containing combination neoadjuvant chemotherapy trials revealed a 5% difference in favor of neoadjuvant chemotherapy. Bladder preservation in selected patients on the basis of response to neoadjuvant chemotherapy is a feasible approach. The goal now must be to find more effective drugs and to better predict the individual response to therapy.
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