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  • Title: Tumor size is associated with the systemic inflammatory response but not survival in patients with primary operable colorectal cancer.
    Author: Crozier JE, McMillan DC, McArdle CS, Angerson WJ, Anderson JH, Horgan PG, McKee RF.
    Journal: J Gastroenterol Hepatol; 2007 Dec; 22(12):2288-91. PubMed ID: 18031394.
    Abstract:
    AIM: To examine the relationship between tumor diameter, C-reactive protein concentrations and survival in patients undergoing surgery for colorectal cancer. METHOD: Tumor diameter and pathological characteristics of the resected specimen were assessed in 227 patients. Circulating concentrations of C-reactive protein were measured prior to surgery. RESULTS: Ninety-six patients had an elevated C-reactive protein concentration (>10 mg/L) prior to surgery. Tumor size was associated with an elevated C-reactive protein concentration (P < 0.001). C-reactive protein concentrations (P < 0.001) were associated with poorer cancer-specific survival. CONCLUSION: Prior to surgery, the maximal tumor diameter is associated with an elevated preoperative C-reactive protein concentration but not survival in patients with primary operable colorectal cancer.
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