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  • Title: Topical administration of leukotriene antagonists in immunogenic keratitis.
    Author: van Delft JL, van Haeringen NJ, Barthen ER, van Best JA, Blackham A.
    Journal: Ophthalmic Res; 1991; 23(6):330-4. PubMed ID: 1803314.
    Abstract:
    Antagonists of leukotriene D4 (LTD4), 3-[7-(2-n-propyl-3-hydroxy-4-acetyl- phenoxy)-propoxy-2-methyl-3,4-dihydro-4-8-n-propyl-2H-1-benzopyran- 2-yl]-propionic acid (SC-39070) and 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxy- propoxy]-4-methyl- 2-oxo-2H-1-benzopyran-3-acetic acid (FPL-60319) were locally administered to eyes of rabbits with immunogenic keratitis. The period of circular leukocyte infiltration (Wessely's ring) in the cornea was markedly decreased. Edema and neovascularization of the cornea were not influenced.
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