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  • Title: Purification and characterization of hepatic microsomal cytochrome P-450 in phenobarbital- and beta-naphthoflavone-treated pigs.
    Author: Thomsen MK, Friis C, Nielsen P.
    Journal: Pharmacol Toxicol; 1991 Nov; 69(5):381-5. PubMed ID: 1803350.
    Abstract:
    Different cytochrome P-450 isoenzymes from hepatic microsomes of phenobarbital (PB) and beta-naphthoflavone (beta-NF) treated pigs and rats were isolated, purified, and characterized. The physico-chemical properties of the porcine isoenzymes were similar to properties of forms isolated from other species. The molecular sizes ranged from 52.5 to 59.5 kD and, in the ferrous-carbonyl state, the isoenzymes had absorbance maxima between 447 and 451 nm. Antigenic similarities were found between the isoenzymes present in PB-induced pigs, and between the isoenzymes present in beta-NF-induced pigs. Cross-reactivity was not observed between PB- and beta-NF-inducible isoenzymes, but beta-NF-inducible isoenzymes in pigs and rats possessed antigenic similarities.
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