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  • Title: Innovations in image-guided radiotherapy.
    Author: Verellen D, De Ridder M, Linthout N, Tournel K, Soete G, Storme G.
    Journal: Nat Rev Cancer; 2007 Dec; 7(12):949-60. PubMed ID: 18034185.
    Abstract:
    The limited ability to control for the location of a tumour compromises the accuracy with which radiation can be delivered to tumour-bearing tissue. The resultant requirement for larger treatment volumes to accommodate target uncertainty restricts the radiation dose because more surrounding normal tissue is exposed. With image-guided radiotherapy (IGRT) these volumes can be optimized and tumoricidal doses can be delivered, achieving maximal tumour control with minimal complications. Moreover, with the ability of high-precision dose delivery and real-time knowledge of the target volume location, IGRT has initiated the exploration of new indications for radiotherapy, some of which were previously considered infeasible.
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