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  • Title: Fluorescent sensor array in a microfluidic chip.
    Author: Basabe-Desmonts L, Benito-López F, Gardeniers HJ, Duwel R, van den Berg A, Reinhoudt DN, Crego-Calama M.
    Journal: Anal Bioanal Chem; 2008 Jan; 390(1):307-15. PubMed ID: 18034337.
    Abstract:
    Miniaturization and automation are highly important issues for the development of high-throughput processes. The area of micro total analysis systems (muTAS) is growing rapidly and the design of new schemes which are suitable for miniaturized analytical devices is of great importance. In this paper we report the immobilization of self-assembled monolayers (SAMs) with metal ion sensing properties, on the walls of glass microchannels. The parallel combinatorial synthesis of sensing SAMs in individually addressable microchannels towards the generation of optical sensor arrays and sensing chips has been developed. [figure: see text] The advantages of microfluidic devices, surface chemistry, parallel synthesis, and combinatorial approaches have been merged to integrate a fluorescent chemical sensor array in a microfluidic chip. Specifically, five different fluorescent self-assembled monolayers have been created on the internal walls of glass microchannels confined in a microfluidic chip.
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