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  • Title: Arterial blood gases during basic life support of human cardiac arrest victims.
    Author: Pytte M, Dorph E, Sunde K, Kramer-Johansen J, Wik L, Steen PA.
    Journal: Resuscitation; 2008 Apr; 77(1):35-8. PubMed ID: 18035475.
    Abstract:
    BACKGROUND: Ventilation with tidal volumes sufficient to raise the victim's chest is an integral part of guidelines for lay-rescuer basic life support, but optimal tidal volume, frequency and ratio to chest compressions are not known. METHODS: Adults with non-traumatic, out-of-hospital cardiac arrest, who were not successfully resuscitated following advanced life support by the staff of a physician-manned ambulance, were included. Advanced life support comprised tracheal intubation and mechanical ventilation with tidal volume of 700 ml and 100% oxygen, 12 times per min. An arterial blood sample was drawn at the end of the resuscitation attempt and analysed on the scene. After the victim was declared dead, basic life support was initiated with chest compressions and mouth-to-mask or mouth-to-tracheal tube ventilation (15:2), with volumes sufficient to make the chest rise. The tracheal tube was equipped with an impedance valve to avoid passive ventilation secondary to chest compressions. Arterial blood samples were drawn after 7-8 min of basic life support and analysed on the scene. RESULTS: Six men and two women, median (range) age 72 (32-86) years, were included in the study. Four of these received mouth-to-mask ventilation and four mouth-to-tracheal tube ventilation. Mean (S.D.) arterial blood carbon dioxide and oxygen tension during advanced life support were 6.4 (1.4)kPa and 22 (15)kPa, respectively. Similar values during basic life support were 9.6 (1.9)kPa and 8.5 (1.6)kPa, respectively, with no differences between the ventilation methods. CONCLUSION: Ventilation during basic life support performed according to international guidelines (2000) resulted in arterial hypercapnia and hypoxia.
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