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  • Title: Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I.
    Author: Parihar MS, Nazarewicz RR, Kincaid E, Bringold U, Ghafourifar P.
    Journal: Biochem Biophys Res Commun; 2008 Feb 01; 366(1):23-8. PubMed ID: 18036554.
    Abstract:
    The present study shows that rat liver and brain mitochondrial nitric oxide synthase (mtNOS) are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, mtNOS exerts high activity and generates nitric oxide, whereas inactivation of complex I leads mtNOS to abandon its NOS activity. Functional association of mtNOS with complex I is potentially important in regulating mtNOS activity and mitochondrial functions.
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