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  • Title: Impact of transfusion dependency and secondary iron overload on the survival of patients with myelodysplastic syndromes.
    Author: Malcovati L.
    Journal: Leuk Res; 2007 Dec; 31 Suppl 3():S2-6. PubMed ID: 18037415.
    Abstract:
    Transfusion dependency is an independent prognostic factor in myelodysplastic syndromes (MDS). The detrimental effect on survival is related to the severity of transfusion requirement and is more noticeable in low-risk patients. Elevated serum ferritin levels have a poor prognostic impact on the survival of transfusion-dependent patients with refractory anemias, and can adversely affect the outcome of patients with MDS receiving allogeneic stem-cell transplantation. Sequential measurements of serum ferritin are useful for measuring secondary iron overload in MDS patients. The implementation of non-invasive methods for assessing tissue iron and organ function should clarify the impact of iron-mediated organ damage on patients with MDS.
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