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  • Title: Improving clinical outcome in patients with myelodysplastic syndrome and iron overload using iron chelation therapy.
    Author: Leitch HA.
    Journal: Leuk Res; 2007 Dec; 31 Suppl 3():S7-9. PubMed ID: 18037416.
    Abstract:
    Until recently, little information on the benefits of iron chelation therapy (ICT) in patients with myelodysplastic syndrome (MDS) and iron overload was known. A recent retrospective study showed improved survival in transfusion-dependent patients with MDS (Low or Intermediate-1 risk IPSS) receiving ICT, compared with those not receiving ICT; median overall survival was not reached at 160 months versus 40 months, respectively. Significantly more patients receiving ICT survived to 4 years (80% versus 44%; p < 0.03), suggesting that MDS patients with iron overload might benefit from ICT. Prospective studies to confirm the benefit of ICT in MDS are warranted.
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