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  • Title: [Beneficial effects of statins and angiotensin converting enzyme inhibitors on aggregability of red blood cells in hypertensive patients].
    Author: Korbut RA, Guzik B, Adamek-Guzik T, Korbut R.
    Journal: Folia Med Cracov; 2006; 47(1-4):37-49. PubMed ID: 18038611.
    Abstract:
    This study was designed to investigate changes in aggregability of red blood cells of patients with essential hypertension and concomitant hypercholesterolemia (total cholesterol level > 5.0 mmol/l) following the use of angiotensin converting enzyme inhibitors (ACE-I) along with or without inhibitor of reductase HMG-CoA (statin). Under standard pharmacotherapy (beta-receptor anatgonist, calcium chanel antagonist, and diuretic) aggregability of RBC in hypertensive patients was significantly increased in spite of the treatment. However, in patients receiving additionally ACE-I spontaneous aggregation of RBC was attenuated. We found that antihypertensive therapy consisting of ACE-I along with statin improved erythrocyte aggregation nearly to the level of normotensive and normocholesterolemic patients. Interestingly, this improvement of blood rheology was observed prior to statin-induced lowering of total cholesterol.
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