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  • Title: Design, synthesis and antimalarial activity of benzene and isoquinoline sulfonamide derivatives.
    Author: Kumar Parai M, Panda G, Srivastava K, Kumar Puri S.
    Journal: Bioorg Med Chem Lett; 2008 Jan 15; 18(2):776-81. PubMed ID: 18039570.
    Abstract:
    A new series of benzene and isoquinoline sulfonamide derivatives were synthesized by nucleophilic displacement reaction on benzene and isoquinoline sulfonyl chlorides by substituted amines (primary and secondary). The title compounds were evaluated for antimalarial activity against Plasmodium falciparum in vitro and showed MIC in the range of 2-50 microg/mL.
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