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  • Title: Serial measurement of serum fructosamine and glycosylated haemoglobin as indices of glycaemic control in diabetic pregnancy.
    Author: Thai AC, Lui KF, Low EG, Ng WY, Kek LP.
    Journal: Ann Acad Med Singap; 1991 Nov; 20(6):732-5. PubMed ID: 1803958.
    Abstract:
    Management of diabetic pregnancy requires objective information regarding blood glucose levels with the aim of achieving strict euglycaemia. Self-blood glucose monitoring and measurement of glycosylated haemoglobin (HbA1) are two methods widely adopted in clinical practice. Serum fructosamine assay was recently introduced as a parameter for assessing short-term glycaemic control. Our study compared serial measurement of serum fructosamine with HbA1 as indices of short-term glycaemic control in a group of diabetic pregnant women prospectively from early/mid-trimester till delivery. Patients performed self-blood glucose glucose concentration of the preceding two weeks were assessed. Our results showed that both serum fructosamine and HbA1 gave comparable information regarding short-term glycaemic control. Serum fructosamine estimation did not offer any distinct additional advantage as a retrospective index of diabetic control in the management of diabetic pregnancy.
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