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  • Title: The effect of vitamin E on granulocyte function in patients with recurrent infections.
    Author: Małkowska-Zwierz W, Garliński P, Zukowska M, Zabuska K, Wartanowicz M, Kleniewska D, Niemirowska H, Izdebska Z, Roszkowski W, Wróblewski T.
    Journal: Arch Immunol Ther Exp (Warsz); 1991; 39(1-2):109-15. PubMed ID: 1804039.
    Abstract:
    The influence of vit. E treatment on metabolic and bactericidal granulocyte activity in patients with recurrent infections was studied by chemiluminescence and phagocytosis assays. Vit. E serum level was significantly diminished before therapy. Six weeks supplementation with 200-300 mg/day of vit. E resulted in improvement of clinical status and normalisation of alpha-tocopherol serum level. Bactericidal activity of granulocytes was lower in patients than in the respective controls and it slightly rose after vit. E therapy. Before, therapy, patients granulocytes showed metabolic activity above or within the control range. Vit. E treatment increased, had no effect or decreased granulocyte metabolic activity, but never below the control range.
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