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  • Title: Ultrastructural study of the neuroglial and macrophagic reaction in Wallerian degeneration of the adult rat optic nerve.
    Author: Carbonell AL, Boya J, Calvo JL, Marin JF.
    Journal: Histol Histopathol; 1991 Oct; 6(4):443-51. PubMed ID: 1804422.
    Abstract:
    The Wallerian degeneration of the optic nerve of adult rat has been studied after destroying the retina. Animals were sacrificed between 4 days and 1 year after the lesion. Different cell types of the optic nerve have been studied ultrastructurally. Our results demonstrate the existence of a population of macrophages, probably of microglial origin, responsible for scavenging degenerated myelin. Astrocytes suffer a process of proliferation and hypertrophy, and are massively stuffed by gliofilaments, leading to a glial scar. These cells apparently do not participate in phagocytic phenomena, while some cytoplasmic inclusions (e.g. lipid droplets) suggest some implication in the local metabolization of some tissue degradation products. Oligodendrocytes do not undergo ultrastructural changes, showing a rather quiescent appearance.
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