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  • Title: [Polymorphism Lys751Gln of XPD gene and breast cancer risk in women].
    Author: Romanowicz-Makowska H, Smolarz B.
    Journal: Pol Merkur Lekarski; 2007 Aug; 23(134):107-9. PubMed ID: 18044339.
    Abstract:
    UNLABELLED: Polymorphisms in DNA repair genes resulting in variation of DNA repair efficiency may therefore be associated with cancer risk. AIM OF THE STUDY: In the present work the distribution of genotypes and frequency of alleles of the Lys751Gln polymorphism of XPD gene in subjects with breast cancer were investigated. MATERIAL AND METHODS: Genomic DNA isolated from 92 breast cancer patients and control (n=110) was used to genotype XPD Lys751Gln by means of polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: The distribution of the genotypes of the Lys751Gln polymorphism of XPD in both control and patients did not differ significantly (p > 0.05) from those predicted by the Hardy-Weinberg distribution. There were no significant differences (p > 0.05) in genotype distributions and allele frequencies between subgroups assigned to histological stage. CONCLUSIONS: The results suggest that the Lys751Gln polymorphism of XPD gene may not be linked with appearance and development of breast cancer.
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