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  • Title: Absence of ethanol-induced interdigitation in supported phospholipid bilayers on silica surfaces.
    Author: Miszta A, van Deursen B, Schoufs R, Hof M, Hermens WT.
    Journal: Langmuir; 2008 Jan 01; 24(1):19-21. PubMed ID: 18044939.
    Abstract:
    Membranes prepared by the adsorption of phospholipid vesicles on solid supports are much-used model systems in biomedical research. However, there is accumulating evidence that such membranes may not always be equivalent to the free-standing cellular membranes that they are modeling. In the present study, sonicated DOPC/DOPS (80/20 mol %) vesicles were adsorbed on hydrophilic silica surfaces, a system that has been demonstrated to produce confluent bilayers. In addition, pure DOPC and DLPC membranes were studied. It is demonstrated that ethanol-induced membrane interdigitation, as demonstrated for free-standing bilayers, does not occur in these supported membranes.
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