These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects and specific binding sites of endothelin in human lung preparations.
    Author: Brink C, Gillard V, Roubert P, Mencia-Huerta JM, Chabrier PE, Braquet P, Verley J.
    Journal: Pulm Pharmacol; 1991; 4(1):54-9. PubMed ID: 1804495.
    Abstract:
    Endothelin binding in human isolated lung membrane fractions revealed a single class of high affinity recognition sites with a Kd of 1.33 +/- 0.15 nM and a Bmax of 9.61 +/- 1.44 pmol/mg protein. Endothelin inhibited [125I]endothelin binding with a Ki of 1.90 +/- 0.15 nM whereas structurally unrelated compounds had no effect. Endothelin was a potent contractile agonist on human isolated pulmonary arterial (HPA) and venous (HPV) muscle preparations (pD2 values: 9.64 and 10.36, respectively). Neither indomethacin (1 microM), nicardipine (0.01, 0.10, 1.0 microM) nor diltiazem (1, 10, 100 microM) altered the sensitivity of HPA to endothelin. Human isolated bronchial muscle preparations were less sensitive to endothelin than vascular tissues. These data suggest that pulmonary veins may be a major target for this constrictory peptide in the human lung.
    [Abstract] [Full Text] [Related] [New Search]