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  • Title: Protein kinase inhibitor H-7 increases lipoprotein lipase activity in isolated rat fat pads.
    Author: Morita T, Tsuruzono Y, Ueki H.
    Journal: Chem Pharm Bull (Tokyo); 1991 Sep; 39(9):2449-50. PubMed ID: 1804558.
    Abstract:
    A protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) increased lipoprotein lipase (LPL) activity in isolated rat fat pads in a time- and dose-dependent manner. The incubation of H-7 with partially purified LPL did not affect its activity. Under the marked inhibition of protein synthesis by cycloheximide, H-7 still showed a full effect on the increase in LPL activity. A slight but significant increase in LPL activity in the fat pads was observed with inhibitors of cyclic nucleotide-dependent protein kinase. H-7, therefore, may increase LPL activity through processes other than the direct activation of the LPL molecule, or the stimulation of LPL molecule synthesis; probably through a decrease in the activity of protein kinases, especially protein kinase C.
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