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  • Title: Indium-copper-mediated barbier-grignard-type alkylation reaction of imines in aqueous media.
    Author: Shen ZL, Loh TP.
    Journal: Org Lett; 2007 Dec 20; 9(26):5413-6. PubMed ID: 18052071.
    Abstract:
    An efficient system of In/CuI/InCl3 was developed for Barbier-Grignard-type alkylation reactions of simple imines, using a one-pot condensation of various aldehydes, amines (including aliphatic and chiral version), and alkyl iodides in water or aqueous media. The reactions proceeded efficiently at room temperature to give the desired products in moderate to good yields. Good diastereoselectivities were obtained when using L-valine methyl ester as substrate.
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