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  • Title: Effects of single administration of morphine on G-protein mRNA level in the presence and absence of inflammation in the rat spinal cord.
    Author: Askari N, Mahboudi F, Haeri-Rohani A, Kazemi B, Sarrami R, Edalat R, Ahmadiani A.
    Journal: Scand J Immunol; 2008 Jan; 67(1):47-52. PubMed ID: 18052964.
    Abstract:
    Antinociceptive potency of opioids is greater against various noxious stimuli in animals with peripheral inflammation. Opioid agonists stimulate activation of G-protein-coupled receptor. Changes in the resting levels of G-protein subtypes could have an effect on intracellular signalling pathways. The present study was designed to investigate the effects of analgesic morphine treatment on the level G-protein subunits mRNA in the presence and absence of inflammation. Our results showed that the carrageenan administration increased G-protein subunits. Administration of analgesic dose of morphine alone and in the presence of inflammation induced different alterations in the levels of G-protein mRNA. Taken together, the results obtained using real time RT-PCR suggested that G-protein genes expression levels following the acute administration of morphine between animals with and without inflammation could influence, at least in part, analgesic responsiveness.
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