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  • Title: Association of MIF-173 gene polymorphism with inflammatory bowel disease in Chinese Han population.
    Author: Fei BY, Lv HX, Yang JM, Ye ZY.
    Journal: Cytokine; 2008 Jan; 41(1):44-7. PubMed ID: 18054247.
    Abstract:
    AIM: To study whether macrophage migration inhibitory factor (MIF)-173 gene polymorphism correlates with inflammatory bowel disease (IBD) in Chinese Han population. METHODS: MIF-173 single nucleotide polymorphism (SNP) was genotyped by tetra-primer amplification refractory mutation system (ARMS) and restriction fragment length polymorphisms (RFLP)-PCR in 142 healthy subjects and 98 patients with inflammatory bowel disease (IBD). RESULTS: There were no discrepancies between the results obtained by tetra-primer ARMS and RFLP-PCR. The frequency of MIF-173 CC genotype was significantly higher in patients with ulcerative colitis (UC) 15.5% than in healthy individuals 5.6% (chi(2)=6.066, P=0.018, OR=3.067 and 95% CI=1.257-7.482). There was a trend towards a higher frequency of CC genotype among CD patients compared with healthy controls, however this did not attain the statistical significance (P=0.245). CONCLUSION: MIF-173 CC genotype may be associated with susceptibility to UC.
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