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Title: Circadian hormonal rhythms in two new cases of fatal familial insomnia. Author: Avoni P, Cortelli P, Montagna P, Tinuper P, Sforza E, Contin M, Parchi P, Pierangeli G, Maltoni P, Pavani A. Journal: Acta Neurol (Napoli); 1991 Dec; 13(6):574-6. PubMed ID: 1805556. Abstract: We used a chronobiological inferential statistical method to investigate circadian rhythms of hypophyseal hormones, cortisol, melatonin and catecholamines in two females of the same family affected by fatal familial insomnia. Case 1 (confirmed at autopsy) presented an absent or progressive loss of circadian rhythms of all hormones. In case 2 there was a loss of GH circadian rhythm and a less significant rhythm for melatonin, catecholamines and gonadotropins. These results confirm the role of the thalamus in regulating hormonal circadian rhythm.[Abstract] [Full Text] [Related] [New Search]