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  • Title: High dose simvastatin does not reverse resistance to vincristine, adriamycin, and dexamethasone (VAD) in myeloma.
    Author: van der Spek E, Bloem AC, Sinnige HA, Lokhorst HM.
    Journal: Haematologica; 2007 Dec; 92(12):e130-1. PubMed ID: 18055977.
    Abstract:
    In a prospective phase II study, we evaluated the combination of high dose simvastatin and VAD chemotherapy in patients with refractory or relapsed multiple myeloma. Although treatment was feasible with mild side effects, only 1 of 12 patients achieved a partial response. According to our predefined criteria this was insufficient to continue the study.
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