These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Byelyankacin: a novel melanogenesis inhibitor produced by Enterobacter sp. B20.
    Author: Takahashi S, Iwai H, Kosaka K, Miyazaki T, Osanai Y, Arao N, Tanaka K, Nagai K, Nakagawa A.
    Journal: J Antibiot (Tokyo); 2007 Nov; 60(11):717-20. PubMed ID: 18057703.
    Abstract:
    A novel melanogenesis inhibitor, byelyankacin (1), was isolated from the fermentation broth of a bacterial strain. The producing organism, designated B20, was identified as a member of the genus Enterobacter based on taxonomic characteristics. 1 was obtained as a white powder from the culture medium by solvent extraction and serial chromatographic purification. The structure of 1 was determined as (E)-4-(2-isocyanovinyl)phenyl alpha-L-rhamnopyranoside on the basis of spectroscopic data. 1 potently inhibited mushroom tyrosinase and melanogenesis of B16-2D2 melanoma cells with IC50 value of 2.1 nM and 30 nM, respectively.
    [Abstract] [Full Text] [Related] [New Search]