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  • Title: Asymmetric synthesis of novel pseudo-D-vinylcyclopropyl nucleosides bearing quaternary carbon as potential anti-herpesvirus agent.
    Author: Park AY, Moon HR, Kim KR, Chun MW, Jeong LS.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2007; 26(8-9):1001-4. PubMed ID: 18058525.
    Abstract:
    Pseudo-D-vinylcyclopropyl nucleosides 10-12 bearing a quaternary carbon were designed and synthesized starting from (R)-epichlorohydrin using a tandem reaction of double alkylation and lactonization via oxirane-ring opening reaction, a Wittig reaction, and chemoselective reduction as potential anti-herpesvirus agent.
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