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  • Title: [Analysis of the replication kinetics in primary culture of isolates of HIV-1 from infected patients in various stages of the disease].
    Author: Fiore JR, Angarano G, Fico C, Di Stefano M, Monno L, Pastore G.
    Journal: Boll Soc Ital Biol Sper; 1991 May; 67(5):529-34. PubMed ID: 1805885.
    Abstract:
    The authors have studied the replicative kinetics and the induction of cytopathic effects of HIV-1 in primary co-cultures from infected subjects at various stages of the disease. Cultures from subjects with ARC or AIDS yielded HIV-1 replication more precociously and at higher levels compared to those from asymptomatic subjects; cytopathic effect "in vitro" were observed more frequently and earlier in cell cultures from ARC/AIDS subjects. Presented data indicate that the clinical and immunological deterioration during HIV-1 infection is related to viral replicative activity and suggest that the study of HIV-1 replicative kinetics in primary co-cultures may be helpful in predicting who will progress to AIDS.
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