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  • Title: Kiss and spit: the dual roles of Toxoplasma rhoptries.
    Author: Boothroyd JC, Dubremetz JF.
    Journal: Nat Rev Microbiol; 2008 Jan; 6(1):79-88. PubMed ID: 18059289.
    Abstract:
    Toxoplasma gondii is a single-celled, eukaryotic parasite that can only reproduce inside a host cell. Upon entry, this Apicomplexan parasite co-opts host functions for its own purposes. An unusual set of apical organelles, named rhoptries, contain some of the machinery that is used by T. gondii both for invasion and to commandeer host functions. Of particular interest are a group of injected protein kinases that are among the most variable of all the T. gondii proteins. At least one of these kinases has a major effect on host-gene expression, including the modulation of key regulators of the immune response. Here, we discuss these recent findings and use them to propose a model in which an expansion of host range is a major force that drives rhoptry-protein evolution.
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