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  • Title: A highly selective fluorescent probe for thiol bioimaging.
    Author: Bouffard J, Kim Y, Swager TM, Weissleder R, Hilderbrand SA.
    Journal: Org Lett; 2008 Jan 03; 10(1):37-40. PubMed ID: 18062694.
    Abstract:
    A new fluorescent turn-on probe (3) for the selective sensing and bioimaging of thiols is reported. In aqueous buffer solutions at physiological pH, thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the red-emissive donor-acceptor fluorophore (4). The probe displays excellent immunity to interference from nitrogen and oxygen nucleophiles and the imaging of thiols in living cells is demonstrated.
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