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  • Title: New 1-indanone thiosemicarbazone derivatives active against BVDV.
    Author: Finkielsztein LM, Castro EF, Fabián LE, Moltrasio GY, Campos RH, Cavallaro LV, Moglioni AG.
    Journal: Eur J Med Chem; 2008 Aug; 43(8):1767-73. PubMed ID: 18063227.
    Abstract:
    Identification of new therapeutic agents for the treatment of viral diseases represents an area of active investigation. In an effort to develop new antiviral compounds, a series of 1-indanone thiosemicarbazone derivatives were synthesized. These derivatives were structurally characterized using several spectroscopic techniques and evaluated against bovine viral diarrhoea virus as a surrogate model for hepatitis C virus. Thiosemicarbazone 2m showed potent anti-bovine viral diarrhoea virus activity with a higher selectivity index (SI=80.29) than that of ribavirin (SI=11.64). This result determines the potentiality of these thiosemicarbazones as antiviral agents for the treatment of infections caused by other highly related members of Flaviviridae family, as hepatitis C virus.
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