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  • Title: Monovalent currents through the T-type Cav3.1 channels and their block by Mg2+.
    Author: Kurejová M, Pavlovicová M, Lacinová L.
    Journal: Gen Physiol Biophys; 2007 Sep; 26(3):234-9. PubMed ID: 18063852.
    Abstract:
    We have investigated the permeability of the Cav3.1 channel for Ca2+ and different monovalent cations and the block of the currents by Mg2+ ions. In the absence of extracellular divalent cations, the Cav3.1 channel was more permeable for Na+ than for Cs+ and impermeable for NMDG+. Monovalent currents were inhibited by Mg2+ of near physiological concentration by three orders of magnitude more effectively than the Ca2+ current. Inhibition of outward, but not inward current by Mg2+ was voltage-dependent. Furthermore, magnesium slowed down channel deactivation presumably by interacting with an open channel state.
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