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  • Title: The fine-tuning of anti-oxidized low-density lipoprotein antibodies in cardiovascular disease and thrombosis.
    Author: Freire de Carvalho J, Sherer Y, Shoenfeld Y.
    Journal: Thromb Haemost; 2007 Dec; 98(6):1157-9. PubMed ID: 18064307.
    Abstract:
    Anti-oxidised low-density lipoprotein (anti-oxLDL) antibodies are a heterogeneous group of autoantibodies including both pathogenic and protective subsets. Whereas in most studies the levels of anti-oxLDL antibodies were associated with enhanced atherosclerosis as evaluated by different methods, immunization with oxLDL leads to elevated levels of anti-oxLDL and protection against atherosclerosis. Anti-oxLDL can also be used for immunomodulation of atherosclerosis (i.e. possible therapeutic use of intravenous immunoglobulin, oral tolerance). More specific autoantibodies out of total anti-oxLDL should be selected, for instance, anti-oxLDL/beta-2-glycoprotein I complex, hence defining the fine-tuning of anti-oxLDL antibodies might detect which autoantibodies are pathogenic and which can be used therapeutically.
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