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  • Title: Treatment of near-skull brain tissue with a focused device using shear-mode conversion: a numerical study.
    Author: Pichardo S, Hynynen K.
    Journal: Phys Med Biol; 2007 Dec 21; 52(24):7313-32. PubMed ID: 18065841.
    Abstract:
    Shear mode transmission through the skull has been previously proposed as a new trans-skull propagation technique for noninvasive therapeutic ultrasound (Clement 2004 J. Acoust. Soc. Am. 115 1356-64). The main advantage of choosing shear over longitudinal mode resides on the fact that there is less wavefront distortion with the former. In the present study, the regions of the brain suitable for shear-mode transmission were established for a simple focused ultrasound device. The device consists of a spherically curved transducer that has a focal length of 10 cm, an aperture between 30 degrees and 60 degrees and operates at 0.74 MHz. The regions suitable for shear-mode transmission were determined by the shear wave acoustic windows that matched the shape of the device acoustic field. The acoustic windows were calculated using segmentation and triangulation of outer and inner faces of skull from 3D-MRI head datasets. Nine heads of healthy adults were analyzed. The surface considered for the calculations was the head region found above the supra-orbital margin. For every inspected point in the brain volume, the axis of the device was determined by the vector between this inspection point and a point located in the center of the brain. Numerical predictions of the acoustic field, where shear-mode conversion through the skull was considered, were obtained and compared to the case of water-only conditions. The brain tissue that is close to the skull showed suitable acoustic windows for shear waves. The central region of the brain seems to be unreachable using shear-mode. Analysis of the acoustic fields showed a proportional relation between the acoustic window for shear mode and the effective degree of focusing. However, this relation showed significant differences among specimens. In general, highly focused fields were obtained when the acoustic window for shear waves (A(SW)) intersected more than 67% of the entering acoustic window (A(TX)) of the device. The average depth from the inner surface of the skull showing this intersection value was 13 +/- 10 mm (mean +/- SD). The differences of the degree of focusing observed among patients suggest that the intersection A(SW) intersection A(TX) can be used as a preliminary criterion for screening and calculation of the acoustic fields should confirm the degree of focusing patient by patient. In conclusion, shear waves provide a useful method for trans-cranial focusing in regions close to the skull surface.
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