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  • Title: Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships.
    Author: de Castro S, Andrei G, Snoeck R, Balzarini J, Camarasa MJ, Velázquez S.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2007; 26(6-7):625-8. PubMed ID: 18066868.
    Abstract:
    TSAO derivatives are a unique group of potent and highly specific inhibitors of HIV-1 replication. We have recently reported 4''-ureido TSAO derivatives that are devoid of anti-HIV-1 activity, but inhibit human cytomegalovirus with an activity comparable to that of Ganciclovir. We herein report the synthesis and biological evaluation of novel 4''-ureido TSAO derivatives in order to evaluate the structural features required for anti-HCMV activity. Interestingly, these studies revealed that the compounds may inhibit HCMV at the DNA polymerase step via a non-nucleoside mechanism.
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