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  • Title: 5-diacetoxymethyl-cycloSal-d4TMP - A prototype of enzymatically activated cycloSal-pronucleotides.
    Author: Gisch N, Balzarini J, Meier C.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2007; 26(6-7):861-4. PubMed ID: 18066914.
    Abstract:
    A new class of "lock-in"-modified cycloSal-pronucleotides has been synthesized. On the example of 5-diacetoxymethyl-cycloSal-d4T-monophosphate (5-di-AM-cycloSal-d4TMP), the concept of enzymatically activated cycloSal-pronucleotides is elucidated. Synthesis, hydrolysis studies, and antiviral activities against HIV are presented.
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