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  • Title: [Factors for recurrence of primary retroperitoneal sarcoma: analysis of 77 cases].
    Author: Qiao MZ, Li CL.
    Journal: Zhonghua Yi Xue Za Zhi; 2007 Sep 25; 87(36):2547-8. PubMed ID: 18067830.
    Abstract:
    OBJECTIVE: To explore the factors influencing the recurrence of retroperitoneal sarcoma. METHODS: The clinical data of 77 patients with primary retroperitoneal sarcoma who were treated with surgery between Jan 1980 and Dec 2005 and followed up for 45.7 months (3.6 - 180.4 months), 36 males and 41 females, aged 49 (24 - 75). RESULTS: 57 cases developed local recurrence and 3 had metastases after surgery. The overall recurrence rate was 74%. The median time between initial surgery and recurrence was 14.8 months (3.2 - 99.6 months). 27 patients died of sarcoma and 5 die of other reasons. The median survival time was 42.5 months (3.6 - 180.4 months). The overall 5-year and 10-year survival rates were 61.7% and 43.9% respectively, and the 5-year and 10-year relapse-free survival rates were 22.7% and 16.8% respectively. Univariate analysis showed that incomplete tumor resection and high-grade tumor were associated with the increased local recurrence rate (P = 0.0008 and P = 0.018). Cox multivariate analysis showed that the only factor found to decrease the risk of local recurrence was complete tumor resection (P = 0.001). CONCLUSION: Complete surgical resection at the time of primary tumor presentation affords the best chance for local control. Patients with high-grade tumor should on the alert for local relapse after surgery.
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