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  • Title: Histologically pure stage I seminoma with an elevated beta-hCG of 4497 IU/l.
    Author: Bjurlin MA, August CZ, Weldon-Linne M, Totonchi E.
    Journal: Urology; 2007 Nov; 70(5):1007.e13-5. PubMed ID: 18068467.
    Abstract:
    Approximately 30% of patients with pure seminoma of the testis have mild elevation of human chorionic gonadotropin (hCG) due to the presence of syncytiotrophoblastic giant cells. Levels are usually less than 500 IU/L; however, the occurrence of higher levels is rare. We report a case of a man with a stage I histologically pure seminoma, copious syncytiotrophoblast cells, and a serum beta human chorionic gonadotropin (beta-hCG) of 4497 IU/L. To our knowledge this is the third highest value of beta-hCG reported with a stage I pure seminoma. The patient underwent an orchiectomy and chemotherapy. His beta-hCG level was undetectable by postoperative day 13, and he remains disease free at 30 months.
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