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  • Title: Caloric restriction and refeeding promoted different metabolic effects in fat depots and impaired dyslipidemic profile in rats.
    Author: Duarte FO, Sene-Fiorese M, Manzoni MS, de Freitas LF, Cheik NC, Garcia de Oliveira Duarte AC, Nonaka KO, Dâmaso A.
    Journal: Nutrition; 2008 Feb; 24(2):177-86. PubMed ID: 18068950.
    Abstract:
    OBJECTIVE: We investigated the effects of severe caloric restriction and refeeding with a high-fat diet on lipid uptake by visceral adipose fat and lipid profile in rats. METHODS: Rats were assigned to six groups: a chow diet (C), a high-fat diet (H), severe caloric restriction (SC and SH), and severe caloric restriction plus refeeding (SC-r and SH-r) during 8 wk. All animals were killed by decapitation 4 h after intragastric administration of [1-14C] triolein ( approximately 0.5 g, 0.3 muCi/rat). Liver; visceral retroperitoneal (RET), epididymal (EPI), and omental (VIS) white adipose tissues; brown adipose tissue; and intestine were immediately removed and weighed. The whole intestine was withdrawn and homogenized to determine lipid uptake. Total cholesterol, high-density lipoprotein (HDL), and triacylglycerol in plasma were determined enzymatically. RESULTS: The SC and SH groups showed reduced visceral adiposity, although this effect was more evident in the SC group. The SC group had greater lipid absorption in the VIS than the C group. The SH treatment increased RET and VIS lipid uptake in relation to the H group. The SH-r treatment increased RET and VIS adiposity. HDL cholesterol decreased with caloric restriction in the SC and SH groups. The SH-r treatment did not increase HDL cholesterol. CONCLUSION: Severe caloric restriction decreased visceral adiposity even in rats in the H group but did not reduce the risk of development of dyslipidemia. Therefore, food restriction plus refeeding with a high-fat diet increase the risk of development of visceral adiposity and dyslipidemia.
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