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  • Title: Prevention of global myocardial reperfusion injury on isolated rabbit hearts with furyl-dihydropyridines I.
    Author: Liu DQ, Zhao DH, Sheng BH.
    Journal: Zhongguo Yao Li Xue Bao; 1991 Jul; 12(4):320-4. PubMed ID: 1807080.
    Abstract:
    In the isolated rabbit heart of recirculating nonpulsatile perfusion circuit, furyl-dihydropyridines I 20 mumol.L-1 greatly reduced the leakage of myocardial enzymes and the concentration of malondialdehyde (MDA) in plasma, decreased the myocardial calcium and sodium contents, maintained normal coronary vascular resistance and prevented reperfusion arrhythmias of global postischemic reperfusion hearts. Its mechanism of protecting the ischemic-reperfused myocardium might be associated with the diminution of calcium influx of myocardial cells and cellular lipid peroxidation induced by oxygen free radicals.
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