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  • Title: Hybrid photoacoustic fluorescence molecular tomography using finite-element-based inversion.
    Author: Razansky D, Ntziachristos V.
    Journal: Med Phys; 2007 Nov; 34(11):4293-301. PubMed ID: 18072494.
    Abstract:
    Improvements in fluorescence reconstruction when utilizing a hybrid photoacoustic (PAT) fluorescence molecular tomography (FMT) method to image optically heterogeneous media are studied and showcased. Quantitative optical absorption maps are retrieved using a normalized backprojection algorithm for PAT reconstruction. Consecutively, the reconstructed absorption distribution is employed into computing a diffusion-equation-based forward model for FMT using a finite-element solution. The potential promise of the suggested method is experimentally verified on tissue-mimicking fluorescent phantoms, where improvements in the quality of FMT reconstructions are observed when imaging at the presence of a large absorber.
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